Blood pH
- Acidosis
occurs when the blood pH is too low.
- Alkalosis
occurs when it is too high.
- During acidosis, chloride
ions, which normally help to control osmotic pressure, do not accompany
sodium ions back into the bloodstream after they are filtered out in the
kidneys. This occurs because bicarbonate ion reabsorption is stepped up
instead, in order to return the blood pH to its normal range
- Normal blood pH is between
7.35 and 7.45.
- Above 7.45 is alkalosis
and below 7.35 is acidosis (physiological acidosis, since
7.35 is technically alkaline).
- Blood pH is maintained through
the bicarbonate buffer system – a mixture of sodium bicarbonate and carbonic
acid in the same solution.
- Carbonic acid is a weak
acid and so does not dissociate readily.
- If a strong acid (HCl,
for example) is added to the system, the bicarbonate ions of the salt tie
up the H+ and form more carbonic acid, lowering the pH of the
entire solution only slightly.
- The weak base, sodium
bicarbonate, does not dissociate readily under alkaline conditions, and
so if a strong base is added (NaOH, for example), carbonic acid will be
forced to dissociate, donating more H+ to tie up the free hydroxyl
groups, and increasing alkalinity only slightly.
- Sodium bicarbonate can
also be replaced with potassium and magnesium salts