Destruction Mechanisms in Blood
- "the red blood cell graveyard"
is a name given to the small circulatory channels in the spleen
. There, old cells can get trapped and subsequently destroyed by macrophages.
- Hemoglobin
is broken down elsewhere.
- First, it is broken down
into heme and globin
- The fate of Heme :
- The iron core
is saved for reuse The rest is degraded to a yellow pigment called
bilirubin.
- Bilirubin is picked
up by the liver, where it is used as a bile pigment.
- There is also sometimes
a green pigment called biliverdin made.
- The fate of bilirubin?
The intestine metabolizes it to urobilinogen , which is further
changed to the brown pigment stercobilin .
- The fate of Globin :
- It is metabolized or
broken down to its component amino acids
Fibrinolysis (destruction of blood clots)
- Removes unneeded blood
clots, naturally!
- Plasmin is
produced from the activation of plasminogen .
- Plasmin is an important
fibrin-digesting enzyme. Because plasminogen is incorporated into a clot,
when it is activated by factors in the endothelial tissue of the vessel,
it destroys the clot from the inside out.
- Fibrinolysis occurs about
2 days after clot formation.